The tropical lowlands of southern Mexico and Central America are composed of a complex mosaic of landscapes that presented a variety of possibilities and challenges to the subsistence practices of the ancient Maya. The Yalahau Regional Human Ecology Project has been investigating ancient Maya agricultural practices and use of resources in a unique fresh-water wetland zone located in the northeast corner of the Yucatán Peninsula. While containing only a sparse population today, the Yalahau region once supported numerous Maya communities and (...) civic-ceremonial centers, particularly during the Late Preclassic and Early Classic periods, between approximately 100 B.C. and A.D. 450. Our investigations have developed evidence that the ancient Maya manipulated and cultivated the wetland landscape of the region, used soil or algae from the wetlands to enrich upland garden plots, and cultivated trees within their communities. We suggest that the study of ancient Maya agricultural practices can contribute to sustainable development of the area today and in the future. (shrink)

In this article, we argue that when teaching about and for social and environmental justice, teachers need to move beyond promoting individual behavior changes as a primary means to counter complex, global problems. Further, we advocate for a more robust strategy for teaching about and for social and environmental justice that not only raises awareness about oppression, inequality, and destruction, but also, and more importantly, interrogates how we define and operationalize the concept of justice. This, we believe, makes for a (...) more educative experience and better prepares students for life in a pluralistic and multicultural society. (shrink)

Do the rich descriptions and narrative shapings of literature provide a valuable resource for readers, writers, philosophers, and everyday people to imagine and confront the ultimate questions of life? Do the human activities of storytelling and complex moral decision-making have a deep connection? What are the moral responsibilities of the artist, critic, and reader? What can religious perspectives—from Catholic to Protestant to Mormon—contribute to literary criticism? Thirty well known contributors reflect on these questions, including iterary theorists Marshall Gregory, James Phelan, (...) and Wayne Booth; philosophers Martha Nussbaum, Richard Hart, and Nina Rosenstand; and authors John Updike, Charles Johnson, Flannery O'Connor, and Bernard Malamud. Divided into four sections, with introductory matter and questions for discussion, this accessible anthology represents the most crucial work today exploring the interdisciplinary connections between literature, religion and philosophy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 389 From the perspective of this reviewer, the presently most obvious fault in this lecture lies in Putnam's criticisms of "the coherence theorists, Ludwig, et al." (p. 97). In this criticism, it is apparently assumed that the adequacy of their proposed solution to the problem considered must be judged solely on the basis of what is presently known. Since Putnam himself acknowledges that no satisfactory interpretation of (...) quantum mechanics exists, this seems unwarranted. The superficiality of the criticism of this position makes this particularly notable. He states, for example, "to say that a wave gives an incomplete description of the state of a system is to say that systems whose state can be described by that wave function may really be in several quite different physical conditions." He then adopts the doubtful strategy of appealing to the meaning of completeness and incompleteness (they are not a matter of degree) in justification of the position that it is improper to say that a wave gives an incomplete descriptionl Despite the fact that, taken as a whole, his brief criticism of the coherence theory is somewhat ungracious. Putnam has set forth the principle issues sur~ rounding the problem with discerning lucidity. Paul K. Feyerabend, in "Problems of Empiricism," places a revisionist's version of empiricism in a carefully developed historical perspective. Empiricism as it has been known is both incomplete and weakened by undesirable assumptions. The incompleteness is to be removed by regarding empiricism as a cosmological hypothesis concerning the relation between man and the universe. The version of empiricism thus admitted has the character of a scientific theory. The undesirable assumptions are views no longer tenable of the nature and content of what is given in sense. Feyerbend understands sensations and perceptions as indicators on a par with indications of physical instruments, and likewise in need of interpretation. A philosophical method is proposed which requires theoretical pluralism instead of the theoretical monism that is (inappropriately) the ideal of much of contemporary empiricism (p. 149). The function of theoretical alternatives is to provide the means of criticizing accepted theory, to which he accords careful historical treatment. "Low level theories" are to guide us to crucial experiments, while "high level theories" are to represent the basic element of the universe. Here again the reader will find a theme which emerges erpeatedly in these lectures. This theme might be stated as follows. Both macrocosmic and microcosmic systems must ultimately be involved in scientific explanation. The crucial problem that emerges is how these two are to be related or in some degree integrated. By the way in which he develops the role of alternative theories, Feyerabend has affirmed one of the principle theoretical components of what Hegel was minded to call metaphysics. An additional observation, for which what I have said should furnish some justification: Many points made throughout this exposition (115 pp. in length) might properly be regarded as together constituting a rapprochement of empiricism and rationalism. It may very well occur to the thoughtful reader that Feyerabend, in his reconstruction of empiricism, has come very near to conceding all that a critical rationalist could ask. Other lectures included in the book are, "The Thermodynamics of Purpose," by David Hawkins, "The Physics of the Large," by Philip Morrison, and "The Ethical Dimension of Scientific Research," by Nicholas Rescher. In the last-mentioned lecture, Professor Rescher points up some generally little understood ethical problems confronted by the scientist in the practice of his profession. DARREL E. CICIRISTENSEN Wo]lord College BOOK NOTES Colin Cherry, On Human Communications: A Review, a Survey, and a Criticism. Cambridge: The M.I.T. Press, 1966. Pp. xiv + 337. (This is an unabridged and unaltered edition of the work first published by the M.I.T. Press in 1957.) $10.00. "In preparation of the current volume, I have examined the original carefully and have decided not to withdraw from anything said there, but merely to add some comments, to up- 390 HISTORY OF PHILOSOPHY date some figures, and to extend the bibliography.... Since detailed reference is impossible, I have decided to restrict the new Bibliography to useful sources of reference, a few of the more significant... (shrink)

The two greatest mathematicians of the early twentieth century, David Hilbert and Henri Poincaré transformed the mathematics of their time. Their personal interaction was infrequent, until Hilbert invited Poincaré to deliver the first Wolfskehl Lectures in Göttingen in the spring of 1909. A correspondence ensued, which fixed the content and timing of the lecture series. A close reading of the exchange throws light on what Hilbert wanted Poincaré to talk about, and on what Poincaré wanted to present to Hilbert and (...) his colleagues. To answer the latter question, reference is made to the published version of Poincaré’s six talks, with a focus on two of them, concerning the propagation of Hertzian waves, and the theory of relativity. (shrink)

Ethical sensitivity triggers the entire ethical decision-making process (i.e., recognition of ethical content in work situations). In this article, five factors are examined that affect tax practitioners' professional ethical sensitivity. The five factors that were examined include role conflict, role ambiguity, job satisfaction, professional commitment, and ethical orientation. Ethical content in work situations is examined in relation to professional ethics as enumerated by the American Institute of Certified Public Accountant's (AICPA) Statements on Responsibilities in Tax Practice (SRTP). Utilizing Hunt and (...) Vitell's (1986, 1993) General Theory of Ethics, a model of ethical sensitivity was constructed and empirically tested. Role conflict negatively and job satisfaction positively influenced tax practitioners' ethical sensitivity. Also, the covariates of the tax practitioner's professional risk level and type of employer were found to be significant. The significant factors are job specific. The tax firm may have the best opportunity to positively change a tax practitioner's ethical recognition abilities. Professional accounting organizations may need to evaluate if resources should be used to formulate, maintain, and publicize codes of conduct because of the lack of significance of professional commitment. (shrink)

In the early 1880s, Henri Poincaré discovered an equilibrium figure for uniformly-rotating fluid masses—the pear, or piriform figure—and speculated that in certain circumstances the pear splits into two unequal parts, and provides thereby a model for the origin of binary stars. The contemporary emergence of photometric and spectroscopic studies of variable stars fueled the first models of eclipsing binaries, and provided empirical support for a realist view of equilibrium figures—including the pear—in the cosmic realm. The paper reviews astrophysical interpretation of (...) the Poincaré pear and the Poincaré-Darwin fission hypothesis with respect to research on variable stars from 1885 to 1901. (shrink)

Prominent atheists claim the Bible is a racist text. Yet Dr. Martin Luther King Jr. read it daily. Then again, so did many ardent segregationists. Some atheists claim religion serves to oppress the masses. Yet the classic text of the French Revolution, What is the Third Estate?, was written by a priest. On the other hand, the revolutionaries ended up banning religion. What do we make of religion's confusing role in history? And what of religion's relationship to science? Some scientists (...) claim that we have no free will. Others argue that advances in neurobiology and physics disprove determinism. As for whispering to the universe, an absurd habit say the skeptics. Yet prayer is a transformative practice for millions. This book explores the most common atheist critiques of the Bible and religion, incorporating Jewish, Christian, and Muslim voices. The result is a fresh, modern re-evaluation of religion and of atheism. (shrink)

This textbook is designed for an Introduction to Proofs course organized around the themes of number and space. Concepts are illustrated using both geometric and number examples, while frequent analogies and applications help build intuition and context in the humanities, arts, and sciences. Sophisticated mathematical ideas are introduced early and then revisited several times in a spiral structure, allowing students to progressively develop rigorous thinking. Throughout, the presentation is enlivened with whimsical illustrations, apt quotations, and glimpses of mathematical history and (...) culture. Early chapters integrate an introduction to sets, logic, and beginning proof techniques with a first exposure to more advanced mathematical structures. The middle chapters focus on equivalence relations, functions, and induction. Carefully chosen examples elucidate familiar topics, such as natural and rational numbers and angle measurements, as well as new mathematics, such as modular arithmetic and beginning graph theory. The book concludes with a thorough exploration of the cardinalities of finite and infinite sets and, in two optional chapters, brings all the topics together by constructing the real numbers and other complete metric spaces. Designed to foster the mental flexibility and rigorous thinking needed for advanced mathematics, Introduction to Mathematics suits either a lecture-based or flipped classroom. A year of mathematics, statistics, or computer science at the university level is assumed, but the main prerequisite is the willingness to engage in a new challenge. (shrink)

What sorts of things are there in the world? Clearly enough, there are concrete, material things; but are there other things too, perhaps nonconcrete or non-material things? Some people believe that there are such things, which are often called abstract ; purported examples of such objects include numbers, properties, possible but non-actual states of affairs, propositions, and sets. Following a long-standing tradition, I shall describe persons who believe that there are abstract objects as ‘platonists’. In this paper, I shall not (...) directly address the plausibility of platonism, as compared with its rivals; instead, I shall confine my attention to one way in which some people have tried to combine platonism and theism. More specifically, I shall concentrate upon the claim that abstract objects depend upon God ontologically ; I shall argue that platonistic theists should reject DEP in favour of the claim that abstract objects exist independently of God . In order to evaluate the relative merits of DEP versus IND, it will be helpful to examine in some detail a particular articulation of DEP. When it comes to recent work on DEP, we can do no better in this regard than to examine the recent work of Thomas V. Morris and Christopher H. Menzel. According Morris and Menzel, there is a sense in which God literally creates such abstracta through engaging in intellective activities. (shrink)

New research demonstrates that mechanics can serve as a means of information propagation in developing embryos. Historically, the study of embryonic development has had a dichotomy between morphogens and pattern formation on the one hand and morphogenesis and mechanics on the other. Secreted signals are the preeminent means of information propagation between cells and used to control cell fate, while physical forces act downstream or in parallel to shape tissue morphogenesis. However, recent work has blurred this division of function by (...) demonstrating that mechanics can serve as a means of information propagation. Adhesive or repulsive interactions can propagate through a tissue as a wave. These waves are rapid and directional and can be used to control the flux of cells through a developmental trajectory. Here, two examples are reviewed in which mechanics both guides and mediates morphogenesis and two examples in which mechanics intertwines with morphogens to regulate cell fate. (shrink)

Academic dishonesty is a persistent problem in the American educational system. The present investigation examined how reports of academic cheating related to students' emphasis on their moral identities and their sensitivity to social evaluation. Seventy college students at a large southeastern university completed a battery of surveys. Symptoms of social anxiety were positively correlated with recall of academic cheating. Additionally, relative to students who placed less importance on their moral identities, students who placed more importance on their moral identities recalled (...) significantly fewer instances of cheating. In summary, these findings suggest that students are less likely to cheat on their school work when they place greater emphasis on their moral identity and are less sensitive to social evaluation. Practical interventions to rampant cheating in American schools are discussed. (shrink)

This volume explores the philosophical issues involved in the idea of petitionary prayer, where this is conceived as an activity designed to influence the action of the all-knowing, all-powerful, perfectly good God of traditional theism. Theists have always recognized various logical and moral limits to divine action in the world, but do these limits leave any space among God's reasons for petitionary prayer to make a difference? Petitionary Prayer: A Philosophical Investigation develops a new account of the conditions required for (...) a petitionary prayer to be answered by employing the notion of contrastive explanation. With careful attention to recent developments in metaphysics, epistemology, and value theory, Scott A. Davison surveys the contemporary literature on this question. He considers questions about human freedom and responsibility in relation to different views of divine providence, along with the puzzles inherent in Christian teachings concerning petitionary prayer. Davison develops new challenges to the coherence of the idea of answered petitionary prayer based upon the nature of divine freedom, the limits of human knowledge, and the nature of those good things that require a recipient's permission before they can be given. He proposes new defences, building upon careful analysis of the shortcomings of previous proposals and clarifying the issues for future debate. (shrink)

Traditional theists believe that there exists an all-knowing, all-powerful, perfectly loving, and perfectly good God. They also believe that God created the world, sustains it in being from moment to moment, and providentially guides all events, in accordance with a plan, towards a good ending. Historically, most traditional theists have believed that God sometimes answers prayers for particular things. In keeping with the literature on this subject, these prayers are referred to as ‘petitionary prayers’. This article discusses several problems related (...) to the concept of the traditional theistic God's answering petitionary prayers. (shrink)

This essay differentiates two approaches to understanding the concept of coercion, and argues for the relative merits of the one currently out of fashion. The approach currently dominant in the philosophical literature treats threats as essential to coercion, and understands coercion in terms of the way threats alter the costs and benefits of an agent’s actions; I call this the “pressure” approach. It has largely superseded the “enforcement approach,” which focuses on the powers and actions of the coercer rather than (...) the perspective of the coercee. The enforcement approach identifies coercion with certain uses of the kinds of powers that agents need to accumulate and wield in order to be able to make significant, credible threats. Though there is considerable overlap extensionally in the instances of coercion recognized by the two approaches, the enforcement approach encompasses some uses of power to coerce that do not involve threats . It also circumscribes which threats should be counted as coercive, though notably it provides a picture of coercion that is non-moralized in its essentials. While there may be specific purposes for which a pressure account is to be preferred, I argue that the enforcement approach better describes how coercion works, and elucidates factors that are often tacitly assumed by pressure accounts. It also is more useful for explaining the social and political significance of coercion, and why coercion is thought to have the implications commonly associated with it. In particular, I argue that it helps us understand why uses of coercion are in general a matter of ethical significance, why state authority depends on commanding a monopoly on the right to use coercion, and why being coerced may reasonably provide one a defense against being held responsible for actions one is coerced into taking. (shrink)

This paper is concerned with the wholly metaphysical question of whether necessity and possibility rest on nonmodal foundations—whether the truth conditions for modal statements are, in the final analysis, nonmodal. It is argued that Lewis’s modal realism is either arbitrary and stipulative or else it is circular. Even if there were Lewisean possible worlds, they could not provide the grounds for modality. D. M. Armstrong’s combinatorial approach to possibility suffers from similar defects. Since more traditional reductions to cognitive or linguistic (...) facts suffer similar fates, the conclusion that the alethic modality is primitive and incapable of reduction is offered. (shrink)

Research programmes are sets of problems preferred on epistemic grounds and including preferred heuristics for inquiry. Charles Lyell's research programme for biogeograpy includes the problem of explaining the distribution of species constrained by laws governing locomotion and containment of species. Included in the programme are laws governing the supernatural introduction of replacement species. Wallace and Darwin derected arguments against the putative intelligibility of this aspect of Lyell's programme before discovering natural selection, and their defence, at this time of natural laws (...) governing the introduction of new species is interesting as a defence of a noval programme of research, not a defence of a proposed theroy. These arguments are presented and an epistemological foundation is offered for them. 1 The author is indebted to a referee for helpful comments on an earlier draft of this paper. (shrink)

We address two major limitations of Schyns et al. First, we clarify their concept of “features” by postulating several levels for processing. The composition of the feature set at each level determines the set at the next higher level, following simple structural guidelines. Second, we show that our proposed framework reconciles feature-creation and fixed-feature approaches.

Recent scholarship in business ethics has revealed the importance of privacy expectations as they relate to implicit privacy norms and the business practices that may violate these expectations. Yet, it is unclear how and when businesses may violate these expectations, factors that form or influence privacy expectations, or whether or not expectations have in fact been violated by company actions. This article reports the findings of three studies exploring how and when the corporate dissemination of consumer data violates privacy expectations. (...) The results indicate that consumer sentiment is more negative following intentional releases of sensitive consumer data, but the effect of data dissemination is more complex than that of company intentionality and data sensitivity alone. Companies can effectively set, and re-affirm, privacy expectations via consent procedures preceding and succeeding data dissemination notifications. Although implied consent has become more widely used in practice, we show how explicit consent outperforms implied consent in these regards. Importantly, this research provides process evidence that identifies perceived violation of privacy expectations as the underlying mechanism to explain the deleterious effects, on consumer sentiment, when company actions are misaligned with consumers’ privacy expectations. Ethical implications for companies collecting and disseminating consumer information are offered. (shrink)

Several prominent theorists have recently advocated reconceptualizing rape as “nonconsensual sex,” omitting the traditional “force” element of the crime. I argue that such a conceptualization fails to capture what is distinctively problematic about rape for women and why rape is pivotal in supporting women’s gender oppression. I argue that conceptualizing rape as coerced sex can replace both the force and nonconsent elements and thereby remedies some of the main difficulties with extant definitions, especially in recognizing “acquaintance” rape as such. I (...) argue that this approach helps explain its distinctive badness both for the individual victims and for women as a group. (shrink)

There are few participants in academic or policy debates over prostitution who would disagree that steps should be taken to improve conditions for those working in prostitution; so Moen1 is in good and plentiful company with respect to his recommendations.I will focus here on the analysis leading up to his conclusions, and with whether it helps us understand why prostitution is so commonly harmful and what it would take to mitigate those harms.i On these matters I am dubious. The question (...) of whether or not prostitution is harmful would seem, manifestly, to be an empirical question, rather than a philosophical issue. I take it that Moen's aim is to clarify the evaluative task, and then to evaluate the arguments that can be made to show prostitution is harmful—tasks which philosophers can responsibly engage in. But I would suggest that Moen's approach to this particular subject oversimplifies it by abstracting away from key facts about the context in which prostitution takes place, and thus that it does not offer as strong a case for normalising prostitution as he hopes.The basic thesis of Moen's essay is that if casual sex is harmless , then the sale of casual sexual services for money is also harmless, or at …. (shrink)

Systematic entomology flourished as a branch of Natural History from the 1750s to the end of the nineteenth century. During this interval, the “era of Heroic Entomology,” the majority of workers in the field were dedicated amateurs. This article traces the demographic and occupational shifts in entomology through this 150-year interval and into the early twentieth century. The survey is based on entomologists who studied beetles (Coleoptera), and who named sufficient numbers of species to have their own names abbreviated by (...) subsequent taxonomists. In the eighteenth century, 27 entomologists achieved this level of prominence, of whom 37% were academics, 19% were doctors, 11% had private incomes, 19% were clergymen, and 8% were government officials. Many of those with private incomes were members of the European aristocracy, and all but one were European men. The nineteenth century list included 192 entomologists, of whom 17% were academics, 16% were museum curators, 2% were school teachers, 15% were doctors, 6% were military men, 7% were merchants, 2% were government entomologists, 6% had private incomes, 5% were clergymen, 5% were government officials, and 4% were lawyers. The demographics of entomology shifted dramatically in the nineteenth century. Whereas many of the noteworthy entomologists of the eighteenth century were German, Swedish, or French, in the nineteenth century, many more European countries are represented, and almost one-fifth of the noteworthy entomologists were from the United States. The nineteenth century list, like the eighteenth century list, contains no women. By the twentieth century, 63% of 178 noteworthy systematic entomologists were paid professionals, teaching entomology courses in universities, or studying insect taxonomy in museums and government-sponsored laboratories. Only one person on the twentieth century list had a private income, but women (ten individuals) were included on the list for the first time. (shrink)

A plausible explanation of the wrongfulness of threatening, advanced most explicitly by Mitchell Berman, is that the wrongfulness of threatening derives from the wrongfulness of the act threatened. This essay argues that this explanation is inadequate. We can learn something important about the wrongfulness of threatening (with implications for thinking about coercion) by comparing credible threats to some other claims of impending harm. A credible bluff threat to do harm is likely to be more and differently wrongful than making intentionally (...) false warnings about other sources of harm. This essay surveys some examples to secure this point, shows that Berman's moralized account of their wrongfulness is wanting, and offers the outline of an approach better suited to explain the wrongfulness of threatening.1. (shrink)

Studies using Posner’s spatial cueing paradigm have demonstrated that participants can allocate their attention to specific target locations based on the predictiveness of preceding cues. Four experiments were conducted to investigate attentional orienting processes operating in a high probability condition as compared to a low probability condition using various types of centrally-presented cues. Spatially-informative cues resulted in cueing effects for both probability conditions, with significantly larger CEs in the high probability conditions than the low probability conditions. Participants in the high (...) probability conditions reported little or no awareness of cue–target probabilities after task completion. Our results provide support for an implicit learning account of the proportion valid effect under experimental conditions involving spatially-informative central cues and relatively short stimulus onset asynchronies. (shrink)

I argue that a well-known argument concerning moral luck supports something like the Principle of Alternate Possibilities (PAP), despite the attacks on PAP by Harry Frankfurt and John Martin Fischer.

A computational modeling approach was used to test one possible explanation for the limited capacity of the subitizing phenomenon. Most existing models of this phenomenon associate the subitizing span with an assumed structural limitation of the human information processing system. In contrast, we show how this limit might emerge as the combinatorics of the space of enumeration problems interacts with the human cognitive architecture in the context of an enumeration task. Subitizing‐like behavior was generated in two different models of enumeration, (...) one based on the ACT‐R cognitive architecture and the other based on the principles of parallel distributed processing (PDP). Our results provide good qualitative fits to results obtained in a variety of empirical studies. (shrink)

The consideration of ‘mutual benefits’ and partner cooperation have long been the accepted standpoint from which to draw inference about the onset, maintenance and breakdown of the coral‐algae endosymbiosis. In this paper, I review recent research into the climate‐induced breakdown of this important symbiosis (namely ‘coral bleaching’) that challenges the validity of this long‐standing belief. Indeed, I introduce a more parsimonious explanation, in which the coral host exerts a ‘controlled parasitism’ over its algal symbionts that is akin to an enforced (...) domestication arrangement. Far from being pathogenic, a range of well‐established cellular processes are reviewed that support the role of the coral host as an active ‘farmer’ of the energy‐rich photoassimilates from its captive symbionts. Importantly, this new paradigm reposes the deleterious bleaching response in terms of an envelope of environmental conditions in which the exploitative and captive measures of the coral host are severely restricted. The ramification of this new paradigm for developing management strategies that may assist the evolution of bleaching resistance in corals is discussed. (shrink)

The data in this special issue are both encouraging and discouraging. On the positive side, researchers are making theoretical breakthroughs into the psychology of the academic cheater, which may result in practical interventions. Yet the studies illustrate the sheer magnitude of the problem and the resources needed to address unethical behavior among the younger members of the American academe. In short, this special issue shows that the "Internet revolution" facilitates new types of academic dishonesty (Sisti, this issue; Stephens, Young, & (...) Calabrese, this issue); that academic cheating is often an intentional, planned act that results from a Machiavellian tendency to neutralize moral sanctions against cheating (Harding, Mayhew, Finelli, & Carpenter, this issue); that motivations to cheat differ across students (Davy, Kincaid, Smith, & Trawick, this issue; Wowra, this issue); and that academic cheating is a symptom of a larger problem (Lovett-Hooper, Komarraju, Weston, & Dollinger, this issue; Wowra, this issue). (shrink)

In this paper, I explore several privacy issues as they arise with respect to the divine/human relationship. First, in section 1, I discuss the notion of privacy in a general way. Section 2 is devoted to the claim that privacy involves control over information about oneself. In section 3, I summarize the arguments offered recently by Margaret Falls-Corbitt and F. Michael McLain for the conclusion that God respects the privacy of human persons by refraining from knowing certain things about them. (...) Finally, in section 4, I shall criticize Falls-Corbitt and McLain’s arguments and make some concluding remarks about God and privacy. (shrink)

Heterogeneity within MDD has hampered identification of biological markers (e.g., intermediate phenotypes, IPs) that might increase risk for the disorder or reflect closer links to the genes underlying the disease process. The newer characterizations of dimensions of MDD within Research Domain Criteria (RDoC) domains may align well with the goal of defining IPs. We compare a sample of 25 individuals with MDD compared to 29 age and education matched controls in multimodal assessment. The multimodal RDoC assessment included the primary IP (...) biomarker, positron emission tomography (PET) with a selective radiotracer for 5-HT1A ([11C]WAY-100635), as well as event-related functional MRI with a Go/No-go task targeting the Cognitive Control network, neuropsychological assessment of affective perception, negative memory bias and Cognitive Control domains. There was also an exploratory genetic analysis with the serotonin transporter (5-HTTLPR) and monamine oxidase A (MAO-A) genes. In regression analyses, lower 5-HT1A binding potential (BP) in the MDD group was related to diminished engagement of the Cognitive Control network, slowed resolution of interfering cognitive stimuli, one element of Cognitive Control. In contrast, higher/normative levels of 5-HT1A BP in MDD (only) was related to a substantial memory bias toward negative information, but intact resolution of interfering cognitive stimuli and greater engagement of Cognitive Control circuitry. The serotonin transporter risk allele was associated with lower 1a BP and the corresponding imaging and cognitive IPs in MDD. Lowered 5HT 1a BP was present in half of the MDD group relative to the control group. Lowered 5HT 1a BP may represent a subtype including decreased engagement of Cognitive Control network and impaired resolution of interfering cognitive stimuli. Future investigations might link lowered 1a BP to neurobiological pathways and markers, as well as probing subtype-specific treatment targets. (shrink)

In this paper I challenge the notion that a healthy and resilient coral is (in all cases) a fast‐growing coral, and by inference, that a reef characterised by a fast trajectory toward high coral cover is necessarily a healthy and resilient reef. Instead, I explain how emerging evidence links fast skeletal extension rates with elevated coral‐algae (symbiotic) respiration rates, most‐often mediated by nutrient‐enlarged symbiont populations and/or rising sea temperatures. Elevated respiration rates can act to reduce the autotrophic capacity (photosynthesis:respiration ratio) (...) of the symbiosis. This restricts the capacity of the coral host to build and maintain sufficient energy reserves (e.g. lipids) needed to sustain essential homeostatic functions, including sexual reproduction and biophysical stress resistance. Moreover, it explains the somewhat paradoxical scenario, whereby at the ecological instant before the reef‐building capacity of the symbiosis is lost, a reef can look visually at its best and be accreting CaCO3 at its maximum. (shrink)